Zebrafish Pronephros: A Model for Understanding Cystic Kidney Disease

Christine L. Hostetter, Jessica L. Sullivan-Brown, Rebecca D. Burdine

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

The embryonic kidney of the zebrafish is the pronephros. The ease of genetic analysis and experimentation in zebrafish, coupled with the simplicity of the pronephros, make the zebrafish an ideal model system for studying kidney development and function. Several mutations have been isolated in zebrafish genetic screens that result in cyst formation in the pronephros. Cloning and characterization of these mutations will provide insight into kidney development but may also provide understanding of the molecular basis of cystic kidney diseases. In this review, we focus on the zebrafish as a model for understanding cystic kidney disease and the links between cystic kidney disease and left-right patterning.

Original languageEnglish (US)
Pages (from-to)514-522
Number of pages9
JournalDevelopmental Dynamics
Volume228
Issue number3
DOIs
StatePublished - Nov 2003

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Keywords

  • Asymmetry
  • Cystic
  • Kidney
  • Pronephros
  • Zebrafish

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