XBumping up kinase activity with an ATP-derived neo-substrate

Ralph E. Kleiner; Tarun M. Kapoor

doi:10.1016/j.cell.2013.07.043

XBumping up kinase activity with an ATP-derived neo-substrate

Ralph E. Kleiner, Tarun M. Kapoor

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.

Original language	English (US)
Pages (from-to)	X716-718
Journal	Cell
Volume	154
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2013.07.043
State	Published - Aug 15 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2013.07.043

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title = "XBumping up kinase activity with an ATP-derived neo-substrate",

abstract = "Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.",

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AU - Kapoor, Tarun M.

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AB - Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.

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M3 - Short survey

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SP - X716-718

JO - Cell

JF - Cell

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XBumping up kinase activity with an ATP-derived neo-substrate

Abstract

All Science Journal Classification (ASJC) codes

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