XBumping up kinase activity with an ATP-derived neo-substrate

Ralph E. Kleiner, Tarun M. Kapoor

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.

Original languageEnglish (US)
Pages (from-to)X716-718
JournalCell
Volume154
Issue number4
DOIs
StatePublished - Aug 15 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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