XBumping up kinase activity with an ATP-derived neo-substrate

Ralph E. Kleiner, Tarun M. Kapoor

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


Pharmacologic agents capable of increasing kinase function would be useful for treating diseases associated with reduced kinase activity, such as inherited forms of Parkinson's disease. In this issue, Hertz et al. report an innovative approach for activating the Parkinson's-associated kinase PINK1 in cells with an ATP-derived neo-substrate.

Original languageEnglish (US)
Pages (from-to)X716-718
Issue number4
StatePublished - Aug 15 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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