Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility

Michelle N. Meyer, Paul S. Appelbaum, Daniel J. Benjamin, Shawneequa L. Callier, Nathaniel Comfort, Dalton Conley, Jeremy Freese, Nanibaa' A. Garrison, Evelynn M. Hammonds, K. Paige Harden, Sandra Soo Jin Lee, Alicia R. Martin, Daphne Oluwaseun Martschenko, Benjamin M. Neale, Rohan H.C. Palmer, James Tabery, Eric Turkheimer, Patrick Turley, Erik Parens

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often-ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk-benefit profile.

Original languageEnglish (US)
Pages (from-to)S2-S49
JournalHastings Center Report
Issue numberS1
StatePublished - Mar 1 2023

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Philosophy
  • Health Policy
  • Issues, ethics and legal aspects


  • behavioral genetics
  • bioethics
  • polygenic index
  • polygenic risk score
  • research ethics
  • sociogenomics


Dive into the research topics of 'Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility'. Together they form a unique fingerprint.

Cite this