@article{7543806534784646920a91483c138713,
title = "Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility",
abstract = "In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often-ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk-benefit profile.",
keywords = "behavioral genetics, bioethics, polygenic index, polygenic risk score, research ethics, sociogenomics",
author = "Meyer, {Michelle N.} and Appelbaum, {Paul S.} and Benjamin, {Daniel J.} and Callier, {Shawneequa L.} and Nathaniel Comfort and Dalton Conley and Jeremy Freese and Garrison, {Nanibaa' A.} and Hammonds, {Evelynn M.} and Harden, {K. Paige} and Lee, {Sandra Soo Jin} and Martin, {Alicia R.} and Martschenko, {Daphne Oluwaseun} and Neale, {Benjamin M.} and Palmer, {Rohan H.C.} and James Tabery and Eric Turkheimer and Patrick Turley and Erik Parens",
note = "Funding Information: The project was funded by the Robert Wood Johnson Foundation, the Russell Sage Foundation, and the JPB Foundation. Additional support comes from Open Philanthropy and The Gil Omenn and Martha Darling Fund for Trusted and Trustworthy Scientific Innovation, a Hastings Center fund. The content is solely the responsibility of the authors and does not necessarily represent the views of any of the funders. Funding Information: We would all like to thank Hastings Center president Mildred Solomon for her unfailing support; Hastings Center former and current research assistant-project managers Isabel Bolo, Ben Wills, Aashna Lal, and Margaret Matthews and Geisinger research assistant Tami Gjorgjieva for excellent research assistance; and Vicki Peyton for excellent administrative support. Finally, we thank professors Vanessa Northington Gamble and Bridget Goosby for helpful conversations early in the project. This special report is a major outcome of a project funded by the Robert Wood Johnson Foundation, the Russell Sage Foundation, and the JPB Foundation. Additional support for this special report comes from The Gil Omenn and Martha Darling Fund for Trusted and Trustworthy Scientific Innovation, a Hastings Center fund. Individual coauthors thank the following additional funders for supporting their time on this project: the National Institute on Aging of the National Institutes of Health (through grants R24-AG065184 and R01-AG042568, supporting Daniel J. Benjamin and Michelle N. Meyer, and grant R00 AG062787, supporting Patrick Turley) and Open Philanthropy (through grant 010623-00001, supporting Benjamin, Turley, and Meyer). Of course, the usual caveat applies: none of these individuals or funding organizations necessarily shares the perspectives reported here. Funding Information: This special report is a major outcome of a project funded by the Robert Wood Johnson Foundation, the Russell Sage Foundation, and the JPB Foundation. Additional support for this special report comes from The Gil Omenn and Martha Darling Fund for Trusted and Trustworthy Scientific Innovation, a Hastings Center fund. Individual coauthors thank the following additional funders for supporting their time on this project: the National Institute on Aging of the National Institutes of Health (through grants R24‐AG065184 and R01‐AG042568, supporting Daniel J. Benjamin and Michelle N. Meyer, and grant R00 AG062787, supporting Patrick Turley) and Open Philanthropy (through grant 010623‐00001, supporting Benjamin, Turley, and Meyer). Publisher Copyright: {\textcopyright} 2023 The Hastings Center.",
year = "2023",
month = mar,
day = "1",
doi = "10.1002/hast.1477",
language = "English (US)",
volume = "53",
pages = "S2--S49",
journal = "Hastings Center Report",
issn = "0093-0334",
publisher = "Hastings Center",
number = "S1",
}