TY - JOUR
T1 - Worldwide patterns of genetic differentiation imply multiple 'domestications' of Aedes aegypti, a major vector of human diseases
AU - Brown, Julia E.
AU - Mcbride, Carolyn S.
AU - Johnson, Petrina
AU - Ritchie, Scott
AU - Paupy, Christophe
AU - Bossin, Hervé
AU - Lutomiah, Joel
AU - Fernandez-Salas, Ildefonso
AU - Ponlawat, Alongkot
AU - Cornel, Anthony J.
AU - Black IV, William C.
AU - Gorrochotegui-Escalante, Norma
AU - Urdaneta-Marquez, Ludmel
AU - Sylla, Massamba
AU - Slotman, Michel
AU - Murray, Kristy O.
AU - Walker, Christopher
AU - Powell, Jeffrey R.
PY - 2011/8/22
Y1 - 2011/8/22
N2 - Understanding the processes bywhich species colonize and adapt tohuman habitats is particularly important in the case of disease-vectoring arthropods. The mosquito species Aedes aegypti, a major vector of dengue and yellow fever viruses, probably originated as a wild, zoophilic species in sub-Saharan Africa, where some populations still breed in tree holes in forested habitats.Many populations of the species, however, have evolved to thrive in human habitats and to bite humans. This includes some populationswithin Africa aswell as almost all those outsideAfrica. It is not clearwhether all domestic populations are genetically related and represent a single 'domestication' event, orwhether associationwith human habitats has developed multiple times independently within the species.To test the hypotheses above,we screened 24worldwide population samples of Ae. aegypti at 12 polymorphic microsatellite loci. We identified two distinct genetic clusters: one included all domestic populations outside of Africa and the other included both domestic and forest populations within Africa. This suggests that human association in Africa occurred independently from that in domestic populations across the rest of the world. Additionally, measures of genetic diversity support Ae. aegypti in Africa as the ancestral form of the species. Individuals from domestic populations outside Africa can reliably be assigned back to their population of origin, which will help determine the origins of new introductions of Ae. aegypti.
AB - Understanding the processes bywhich species colonize and adapt tohuman habitats is particularly important in the case of disease-vectoring arthropods. The mosquito species Aedes aegypti, a major vector of dengue and yellow fever viruses, probably originated as a wild, zoophilic species in sub-Saharan Africa, where some populations still breed in tree holes in forested habitats.Many populations of the species, however, have evolved to thrive in human habitats and to bite humans. This includes some populationswithin Africa aswell as almost all those outsideAfrica. It is not clearwhether all domestic populations are genetically related and represent a single 'domestication' event, orwhether associationwith human habitats has developed multiple times independently within the species.To test the hypotheses above,we screened 24worldwide population samples of Ae. aegypti at 12 polymorphic microsatellite loci. We identified two distinct genetic clusters: one included all domestic populations outside of Africa and the other included both domestic and forest populations within Africa. This suggests that human association in Africa occurred independently from that in domestic populations across the rest of the world. Additionally, measures of genetic diversity support Ae. aegypti in Africa as the ancestral form of the species. Individuals from domestic populations outside Africa can reliably be assigned back to their population of origin, which will help determine the origins of new introductions of Ae. aegypti.
KW - Aedes aegypti aegypti
KW - Aedes aegypti formosus
KW - Evolution
KW - Human habitats
KW - Microsatellites
KW - Mosquito genetics
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U2 - 10.1098/rspb.2010.2469
DO - 10.1098/rspb.2010.2469
M3 - Article
C2 - 21227970
AN - SCOPUS:79960141450
SN - 0962-8452
VL - 278
SP - 2446
EP - 2454
JO - Proceedings of the Royal Society B: Biological Sciences
JF - Proceedings of the Royal Society B: Biological Sciences
IS - 1717
ER -