Working Memory Load Modulates Neuronal Coupling

Dimitris A. Pinotsis, Timothy J. Buschman, Earl K. Miller

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

There is a severe limitation in the number of items that can be held in working memory. However, the neurophysiological limits remain unknown. We asked whether the capacity limit might be explained by differences in neuronal coupling. We developed a theoretical model based on Predictive Coding and used it to analyze Cross Spectral Density data from the prefrontal cortex (PFC), frontal eye fields (FEF), and lateral intraparietal area (LIP). Monkeys performed a change detection task. The number of objects that had to be remembered (memory load) was varied (1-3 objects in the same visual hemifield). Changes in memory load changed the connectivity in the PFC-FEF-LIP network. Feedback (top-down) coupling broke down when the number of objects exceeded cognitive capacity. Thus, impaired behavioral performance coincided with a break-down of Prediction signals. This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load.

Original languageEnglish (US)
Pages (from-to)1670-1681
Number of pages12
JournalCerebral Cortex
Volume29
Issue number4
DOIs
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Keywords

  • biophysical modeling
  • cognitive capacity
  • prefrontal cortex
  • synchrony
  • working memory

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