Widespread functional connectivity and fMRI fluctuations in human visual cortex in the absence of visual stimulation

Yuval Nir, Uri Hasson, Ifat Levy, Yehezkel Yeshurun, Rafael Malach

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

To what extent does the visual system's activity fluctuate when no sensory stimulation is present? Here, we studied this issue by examining spontaneous fluctuations in BOLD signal in the human visual system, while subjects were placed in complete darkness. Our results reveal widespread slow fluctuations during such rest periods. In contrast to stimulus-driven activity, during darkness, functionally distinct object areas were fluctuating in unison. These fMRI fluctuations became rapidly spatially de-correlated (39% drop in correlation level, P < 0.008) during visual stimulation. Functional connectivity analysis revealed that the slow spontaneous fluctuations during rest had consistent and specific neuro-anatomical distribution which argued against purely hemodynamic noise sources. Control experiments ruled out eye closure, low luminance and mental imagery as the underlying sources of the spontaneous fluctuations. These results demonstrate that, when no stimulus is present, sensory systems manifest a robust level of slow organized fluctuation patterns.

Original languageEnglish (US)
Pages (from-to)1313-1324
Number of pages12
JournalNeuroimage
Volume30
Issue number4
DOIs
StatePublished - May 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Keywords

  • De-coherence
  • Functional connectivity
  • Ongoing activity
  • Rest activity
  • Spontaneous activity

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