Why do some coronaviruses become pandemic threats when others do not?

Benjamin L. Rice, Justin Lessler, Clifton McKee, C. Jessica E. Metcalf

Research output: Contribution to journalArticlepeer-review

Abstract

ADUes:pPiteleamsuecltoipnlfeirsmptihllaotvaellrheeavdeinntgsleavnedlsasrheorretpcrhesaeinntsedocfotrrarencstmly:ission on at least 4 continents, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has never triggered a pandemic. By contrast, its relative, Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV- 2) has, despite apparently little, if any, previous circulation in humans. Resolving the unsolved mystery of the failure of MERS-CoV to trigger a pandemic could help inform how we understand the pandemic potential of pathogens, and probing it underscores a need for a more holistic understanding of the ways in which viral genetic changes scale up to population- level transmission.

Original languageEnglish (US)
Article numbere3001652
JournalPLoS biology
Volume20
Issue number5
DOIs
StatePublished - May 2022

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Fingerprint

Dive into the research topics of 'Why do some coronaviruses become pandemic threats when others do not?'. Together they form a unique fingerprint.

Cite this