Whole-genome analysis of Drosophila gastrulation

Angelike Stathopoulos, Michael Levine

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Microarray assays and bioinformatics methods have identified many of the genes and associated regulatory DNAs that control the early phases of gastrulation in Drosophila. The localized activities of these genes are coordinated by a nuclear gradient of the maternal regulatory factor, Dorsal, that is established shortly after fertilization. At least half of the Dorsal target genes encode transcription factors or signaling components that lead to the restricted activation of FGF, EGF, and TGF-β signaling pathways in the mesoderm, neurogenic ectoderm and dorsal ectoderm, respectively. Recent work has yielded insights into how these signaling pathways control gastrulation, particularly in the context of the Dorsal-mediated gene regulation network.

Original languageEnglish (US)
Pages (from-to)477-484
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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