Whole-genome analysis of Dorsal-ventral patterning in the Drosophila embryo

Angelike Stathopoulos, Madeleine Van Drenth, Albert Erives, Michele Markstein, Michael Levine

Research output: Contribution to journalArticlepeer-review

245 Scopus citations


The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tissue-specific form of the NF-Y transcription complex is essential for the activation of gene expression in the mesoderm. Tissue-specific enhancers were identified for new Dorsal target genes, and bioinformatics methods identified conserved cis-regulatory elements for coordinately regulated genes that respond to similar thresholds of the Dorsal gradient. The new Dorsal target genes and enhancers represent one of the most extensive gene networks known for any developmental process.

Original languageEnglish (US)
Pages (from-to)687-701
Number of pages15
Issue number5
StatePublished - Nov 27 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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