Abstract
High-resolution Micro-C maps identified a specialized class of regulatory DNAs termed ‘tethering elements’ (TEs) in Drosophila. These 300–500-bp elements facilitate specific long-range genomic associations or loops. The POZ-containing transcription factor GAF (GAGA-associated factor) contributes to loop formation. Tether–tether interactions accelerate Hox gene activation by distal enhancers, and coordinate transcription of duplicated genes (paralogs) through promoter–promoter associations. Some TEs engage in ultra-long-range enhancer–promoter and promoter–promoter interactions (meta-loops) in the Drosophila brain. We discuss the basis for tether–tether specificity and speculate on the occurrence of similar elements in vertebrate genomes.
Original language | English (US) |
---|---|
Article number | 102151 |
Journal | Current Opinion in Genetics and Development |
Volume | 84 |
DOIs | |
State | Published - Feb 2024 |
All Science Journal Classification (ASJC) codes
- Genetics
- Developmental Biology