Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

Maša Alečković, Yibin Kang

Research output: Contribution to journalShort survey

14 Scopus citations

Abstract

Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.

Original languageEnglish (US)
Pages (from-to)554-556
Number of pages3
JournalCancer Cell
Volume28
Issue number5
DOIs
StatePublished - Nov 9 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

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