Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Nov 9 2015|
All Science Journal Classification (ASJC) codes
- Cell Biology
- Cancer Research