Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

Maša Alečković; Yibin Kang

doi:10.1016/j.ccell.2015.10.010

Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

Maša Alečković, Yibin Kang

Research output: Contribution to journal › Short survey › peer-review

23 Scopus citations

Abstract

Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.

Original language	English (US)
Pages (from-to)	554-556
Number of pages	3
Journal	Cancer Cell
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2015.10.010
State	Published - Nov 9 2015

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research
Cell Biology

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10.1016/j.ccell.2015.10.010

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title = "Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis",

abstract = "Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.",

author = "Ma{\v s}a Ale{\v c}kovi{\'c} and Yibin Kang",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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doi = "10.1016/j.ccell.2015.10.010",

language = "English (US)",

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T2 - Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

AU - Alečković, Maša

AU - Kang, Yibin

PY - 2015/11/9

Y1 - 2015/11/9

N2 - Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.

AB - Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.

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U2 - 10.1016/j.ccell.2015.10.010

DO - 10.1016/j.ccell.2015.10.010

M3 - Short survey

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SN - 1535-6108

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JO - Cancer Cell

JF - Cancer Cell

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ER -

Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

Abstract

All Science Journal Classification (ASJC) codes

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