@article{b1da3bb41a384323a23ddf83270658a4,
title = "Weak dorsolateral prefrontal response to social criticism predicts worsened mood and symptoms following social conflict in people at familial risk for schizophrenia",
abstract = "Understanding the specific mechanisms that explain why people who have relatives with schizophrenia (i.e., people at familial high risk; FHR) are more likely to develop the disorder is crucial for prevention. We investigated a diathesis-stress model of familial risk by testing whether FHR individuals under-recruit brain regions central to emotion regulation when exposed to social conflict, resulting in worse mood and symptoms following conflict. FHR and non-FHR participants listened to critical, neutral, and praising comments in an fMRI scanner before completing 4 weeks of daily-diary records. Compared to non-FHR individuals, FHR individuals under-recruited the bilateral dorsolateral prefrontal cortex (DLPFC)—a region strongly implicated in cognitive emotion regulation—following criticism. Furthermore, within FHR participants, weak DLPFC response to criticism in the laboratory task was associated with elevated negative mood and positive symptoms on days with distressing social conflicts in daily-diary assessments. Results extend diathesis-stress models of schizophrenia by clarifying neural and environmental pathways to dysregulation in FHR individuals.",
keywords = "DLPFC, Emotion regulation, Expressed emotion, Familial high risk, Schizophrenia",
author = "Nook, {Erik C.} and David Dodell-Feder and Germine, {Laura T.} and Hooley, {Jill M.} and DeLisi, {Lynn E.} and Hooker, {Christine I.}",
note = "Funding Information: This research was supported by an award from the Milton Fund to CIH, a National Science Foundation Graduate Research Fellowship ( DGE1144152 ) to ECN, a training grant from the National Institutes of Health Blueprint for Neuroscience Research ( T90DA022759/R90DA023427 ) to DD-F, the Sackler Scholar Programme in Psychobiology to DD-F, and, indirectly, by a National Institute of Mental Health Award R21MH083205 to LED that helped create recruitment infrastructure. This article's contents are the responsibility of the authors and do not necessarily represent the official views of the NIH or other funding agencies. Funding Information: This research was supported by an award from the Milton Fund to CIH, a National Science Foundation Graduate Research Fellowship (DGE1144152) to ECN, a training grant from the National Institutes of Health Blueprint for Neuroscience Research (T90DA022759/R90DA023427) to DD-F, the Sackler Scholar Programme in Psychobiology to DD-F, and, indirectly, by a National Institute of Mental Health Award R21MH083205 to LED that helped create recruitment infrastructure. This article's contents are the responsibility of the authors and do not necessarily represent the official views of the NIH or other funding agencies. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
doi = "10.1016/j.nicl.2018.01.004",
language = "English (US)",
volume = "18",
pages = "40--50",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",
}