Wave propagation in the early stages of aggregation of cellular slime molds

Morrel H. Cohen, Anthony Robertson

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

A detailed theory of the velocity of propagation of the acrasin pulse responsible for the aggregation of some of the cellular slime molds is presented. The ingredients are diffusion of acrasin, triggering after a threshold concentration is reached, an intracellular delay between the reaching of threshold and subsequent release of acrasin, the destruction of acrasin by acrasinase, and an intracellular refractory period. It is suggested that the rate limiting factor in the velocity of propagation is probably the intracellular delay and not intercellular diffusion. It is shown that there is a critical density of amebae below which the waves cannot propagate. The number of neighboring amebae triggered simultaneously by the propagating wave, and therefore the spatial width of the pulse tends to increase with density. Rough estimates are given for the number of acrasin molecules per pulse and for its threshold concentration.

Original languageEnglish (US)
Pages (from-to)101-118
Number of pages18
JournalJournal of Theoretical Biology
Volume31
Issue number1
DOIs
StatePublished - Apr 1971
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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