Water-like solvation thermodynamics in a spherically symmetric solvent model with two characteristic lengths

Sergey V. Buldyrev, Pradeep Kumar, Pablo G. Debenedetti, Peter J. Rossky, H. Eugene Stanley

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

We examine by molecular dynamics simulation the solubility of small apolar solutes in a solvent whose particles interact via the Jagla potential, a spherically symmetric ramp potential with two characteristic lengths: an impenetrable hard core and a penetrable soft core. The Jagla fluid has been recently shown to possess water-like structural, dynamic, and thermodynamic anomalies. We find that the solubility exhibits a minimum with respect to temperature at fixed pressure and thereby show that the Jagla fluid also displays water-like solvation thermodynamics. We further find low-temperature swelling of a hard-sphere chain dissolved in the Jagla fluid and relate this phenomenon to cold unfolding of globular proteins. Our results are consistent with the possibility that the presence of two characteristic lengths in the Jagla potential is a key feature of water-like solvation thermodynamics. The penetrable core becomes increasingly important at low temperatures, which favors the formation of low-density, open structures in the Jagla solvent.

Original languageEnglish (US)
Pages (from-to)20177-20182
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number51
DOIs
StatePublished - Dec 18 2007

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Aqueous solubility
  • Cold denaturation
  • Hydrophobic hydration
  • Jagla model
  • Water anomalies

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