Only one species of double-stranded RNA (20S) is found in BHK-21 cells after infection with plaque-purified Sindbis virus. A smaller species of double-stranded RNA (12S), which is shown to contain viral sequences by hydridization experiments, is present when BHK-21 cells are infected at high multiplicities with a Sindbis virus stock derived by repeated passage at high multiplicity of infection. Several small single-stranded RNA species (0.9 to 2.2 × 105 MW) not found in cells infected with plaque-purified virus are present in infected cells which contain 12S DS RNA.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Oct 6 1972|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology