Viral regulation of organelle membrane contact sites

William A. Hofstadter, Elene Tsopurashvili, Ileana M. Cristea

Research output: Contribution to journalArticlepeer-review


AU At the: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly core of organelle functions lies their ability and need to: form dynamic organelle–organelle networks that drive intracellular communication and coordination of cellular pathways. These networks are facilitated by membrane contact sites (MCSs) that promote both intra-organelle and inter-organelle communication. Given their multiple functions, MCSs and the proteins that form them are commonly co-opted by viruses during infection to promote viral replication. This Essay discusses mechanisms acquired by diverse human viruses to regulate MCS functions in either proviral processes or host defense. It also examines techniques used for examining MCSs in the context of viral infections.

Original languageEnglish (US)
Article numbere3002529
JournalPLoS biology
Issue number3
StatePublished - Mar 2024

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • General Agricultural and Biological Sciences


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