@article{00daa09292be43f59c7e2923b0fda17c,
title = "VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors",
abstract = "Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cure rate for breast cancer. Here, we characterize a bone metastasis dormancy model to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-κB pathway, promotes the transition from indolent micrometastasis to overt metastasis. By interacting with the cognate receptor integrin α4β1, VCAM-1 recruits monocytic osteoclast progenitors and elevates local osteoclast activity. Antibodies against VCAM-1 and integrin α4 effectively inhibit bone metastasis progression and preserve bone structure. These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone.",
author = "Xin Lu and Euphemia Mu and Yong Wei and Sabine Riethdorf and Qifeng Yang and Min Yuan and Jun Yan and Yuling Hua and Tiede, {Benjamin J.} and Xuemin Lu and Haffty, {Bruce G.} and Klaus Pantel and Joan Massagu{\'e} and Yibin Kang",
note = "Funding Information: We thank S. Thiberge for two-photon microscopy analysis; C. DeCoste and M. Bisher for assistance with flow cytometry and electron microscopy; D. Medina and M. Zhang for TM40D cell lines; L. Cong, J. Friedman, and L. Goodell at Tissue Analytic Service Core of Cancer Institute of New Jersey for assistance with TMA analysis; and L. Mercatali, T. Ibrahim, D. Amadori, and M. Reiss for tissue analysis and helpful discussions. The Imaging Core Facility at the Lewis-Sigler Institute is supported by the Center Grant P50GM071508. Y.K. is a Champalimaud Investigator and a Department of Defense Era of Hope Scholar Award recipient. This research was additionally supported by grants from the Breast Cancer Alliance, Susan G. Komen for the Cure, the American Cancer Society, and the Brewster Foundation (to Y.K.) and from the Breast Cancer Research Foundation (to B.G.H.). J.M. is an Investigator of the Howard Hughes Medical Institute and is funded by grants from the National Institutes of health, the Kleberg Foundation, the Hearst Foundation, and the BBVA Foundation. X.L. is a recipient of the Harold W. Dodds Fellowship from Princeton University. Y.H. and B. T. are recipients of the DOD predoctoral fellowships. ",
year = "2011",
month = dec,
day = "13",
doi = "10.1016/j.ccr.2011.11.002",
language = "English (US)",
volume = "20",
pages = "701--714",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",
}