Variation in gene expression patterns in human gastric cancers

Xin Chen, Suet Y. Leung, Siu T. Yuen, Kent Man Chu, Jiafu Ji, Rui Li, Annie S.Y. Chan, Simon Law, Olga G. Troyanskaya, John Wong, Samuel So, David Botstein, Patrick O. Brown

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237 Scopus citations

Abstract

Gastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)3208-3215
Number of pages8
JournalMolecular biology of the cell
Volume14
Issue number8
DOIs
StatePublished - Aug 1 2003

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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    Chen, X., Leung, S. Y., Yuen, S. T., Chu, K. M., Ji, J., Li, R., Chan, A. S. Y., Law, S., Troyanskaya, O. G., Wong, J., So, S., Botstein, D., & Brown, P. O. (2003). Variation in gene expression patterns in human gastric cancers. Molecular biology of the cell, 14(8), 3208-3215. https://doi.org/10.1091/mbc.E02-12-0833