TY - JOUR
T1 - Variation in gene expression patterns in follicular lymphoma and the response to rituximab
AU - Bohen, Sean P.
AU - Troyanskaya, Olga G.
AU - Alter, Orly
AU - Warnke, Roger
AU - Botstein, David
AU - Brown, Patrick O.
AU - Levy, Ronald
PY - 2003/2/18
Y1 - 2003/2/18
N2 - Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from rituximab responders. These findings suggest the possibility that the response of follicular lymphoma to rituximab treatment may be predicted from the gene expression pattern of tumors.
AB - Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from rituximab responders. These findings suggest the possibility that the response of follicular lymphoma to rituximab treatment may be predicted from the gene expression pattern of tumors.
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U2 - 10.1073/pnas.0437875100
DO - 10.1073/pnas.0437875100
M3 - Article
C2 - 12571354
AN - SCOPUS:0037452616
SN - 0027-8424
VL - 100
SP - 1926
EP - 1930
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 4
ER -