Variation in gene expression patterns in follicular lymphoma and the response to rituximab

Sean P. Bohen, Olga G. Troyanskaya, Orly Alter, Roger Warnke, David Botstein, Patrick O. Brown, Ronald Levy

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from rituximab responders. These findings suggest the possibility that the response of follicular lymphoma to rituximab treatment may be predicted from the gene expression pattern of tumors.

Original languageEnglish (US)
Pages (from-to)1926-1930
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number4
DOIs
StatePublished - Feb 18 2003

All Science Journal Classification (ASJC) codes

  • General

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