Using whole-genome transcriptional analyses to identify molecular mechanisms of aging

Coleen T. Murphy

doi:10.1016/j.ddmec.2006.02.012

Using whole-genome transcriptional analyses to identify molecular mechanisms of aging

Coleen T. Murphy

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Whole-genome transcriptional analyses of aging organisms and tissues have revealed changes in many genes and biological processes. A comparison of these studies reveals common age-related changes, including the downregulation of metabolic and mitochondrial function, and the upregulation of stress and immune responses. This suggests that much of the aging process might be conserved across species, although tissue- and species-specific changes also occur. These comparisons will help identify the underlying mechanisms of aging.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Drug Discovery Today: Disease Mechanisms
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.ddmec.2006.02.012
State	Published - 2006

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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10.1016/j.ddmec.2006.02.012

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title = "Using whole-genome transcriptional analyses to identify molecular mechanisms of aging",

abstract = "Whole-genome transcriptional analyses of aging organisms and tissues have revealed changes in many genes and biological processes. A comparison of these studies reveals common age-related changes, including the downregulation of metabolic and mitochondrial function, and the upregulation of stress and immune responses. This suggests that much of the aging process might be conserved across species, although tissue- and species-specific changes also occur. These comparisons will help identify the underlying mechanisms of aging.",

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N2 - Whole-genome transcriptional analyses of aging organisms and tissues have revealed changes in many genes and biological processes. A comparison of these studies reveals common age-related changes, including the downregulation of metabolic and mitochondrial function, and the upregulation of stress and immune responses. This suggests that much of the aging process might be conserved across species, although tissue- and species-specific changes also occur. These comparisons will help identify the underlying mechanisms of aging.

AB - Whole-genome transcriptional analyses of aging organisms and tissues have revealed changes in many genes and biological processes. A comparison of these studies reveals common age-related changes, including the downregulation of metabolic and mitochondrial function, and the upregulation of stress and immune responses. This suggests that much of the aging process might be conserved across species, although tissue- and species-specific changes also occur. These comparisons will help identify the underlying mechanisms of aging.

UR - https://www.scopus.com/pages/publications/33745880714

UR - https://www.scopus.com/pages/publications/33745880714#tab=citedBy

U2 - 10.1016/j.ddmec.2006.02.012

DO - 10.1016/j.ddmec.2006.02.012

M3 - Review article

AN - SCOPUS:33745880714

SN - 1740-6765

VL - 3

SP - 41

EP - 46

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 1

ER -

Using whole-genome transcriptional analyses to identify molecular mechanisms of aging

Abstract

All Science Journal Classification (ASJC) codes

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