Using whole-genome transcriptional analyses to identify molecular mechanisms of aging

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Whole-genome transcriptional analyses of aging organisms and tissues have revealed changes in many genes and biological processes. A comparison of these studies reveals common age-related changes, including the downregulation of metabolic and mitochondrial function, and the upregulation of stress and immune responses. This suggests that much of the aging process might be conserved across species, although tissue- and species-specific changes also occur. These comparisons will help identify the underlying mechanisms of aging.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume3
Issue number1
DOIs
StatePublished - Jul 19 2006

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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