Us9-independent axonal sorting and transport of the pseudorabies virus glycoprotein gM

R. Kratchmarov, L. W. Enquist, M. P. Taylor

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Axonal sorting and transport of fully assembled pseudorabies virus (PRV) virions is dependent on the viral protein Us9. Here we identify a Us9-independent mechanism for axonal localization of viral glycoproteinM(gM). We detected gM-mCherry assemblies transporting in the anterograde direction in axons. Furthermore, unlabeled gM, but not glycoprotein B, was detected by Western blotting in isolated axons during Us9-null PRV infection. These results suggest that gM differs from other viral proteins regarding axonal transport properties.

Original languageEnglish (US)
Pages (from-to)6511-6514
Number of pages4
JournalJournal of virology
Volume89
Issue number12
DOIs
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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