Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Yang Zhang; Yi Xu; Wenyun Lu; Jonathan M. Ghergurovich; Lili Guo; Ian A. Blair; Joshua D. Rabinowitz; Xiaolu Yang

doi:10.1016/j.cmet.2020.10.002

Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Yang Zhang
, Yi Xu
, Wenyun Lu
, Jonathan M. Ghergurovich
, Lili Guo
, Ian A. Blair
, Joshua D. Rabinowitz
, Xiaolu Yang

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.

Original language	English (US)
Pages (from-to)	94-109.e8
Journal	Cell Metabolism
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2020.10.002
State	Published - Jan 5 2021

All Science Journal Classification (ASJC) codes

Molecular Biology
Physiology
Cell Biology

Keywords

G6PD
NAD kinase
NADPH
antioxidants
cancer metabolism
nucleosides
nucleotide synthesis
oncogenic transformation
pentose phosphate pathway
redox regulation

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10.1016/j.cmet.2020.10.002

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title = "Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation",

abstract = "The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.",

keywords = "G6PD, NAD kinase, NADPH, antioxidants, cancer metabolism, nucleosides, nucleotide synthesis, oncogenic transformation, pentose phosphate pathway, redox regulation",

author = "Yang Zhang and Yi Xu and Wenyun Lu and Ghergurovich, \{Jonathan M.\} and Lili Guo and Blair, \{Ian A.\} and Rabinowitz, \{Joshua D.\} and Xiaolu Yang",

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doi = "10.1016/j.cmet.2020.10.002",

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T1 - Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

AU - Zhang, Yang

AU - Xu, Yi

AU - Lu, Wenyun

AU - Ghergurovich, Jonathan M.

AU - Guo, Lili

AU - Blair, Ian A.

AU - Rabinowitz, Joshua D.

AU - Yang, Xiaolu

PY - 2021/1/5

Y1 - 2021/1/5

N2 - The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.

AB - The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.

KW - G6PD

KW - NAD kinase

KW - NADPH

KW - antioxidants

KW - cancer metabolism

KW - nucleosides

KW - nucleotide synthesis

KW - oncogenic transformation

KW - pentose phosphate pathway

KW - redox regulation

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UR - https://www.scopus.com/pages/publications/85096600711#tab=citedBy

U2 - 10.1016/j.cmet.2020.10.002

DO - 10.1016/j.cmet.2020.10.002

M3 - Article

C2 - 33159852

AN - SCOPUS:85096600711

SN - 1550-4131

VL - 33

SP - 94-109.e8

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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