Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Yang Zhang; Yi Xu; Wenyun Lu; Jonathan M. Ghergurovich; Lili Guo; Ian A. Blair; Joshua D. Rabinowitz; Xiaolu Yang

doi:10.1016/j.cmet.2020.10.002

Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Yang Zhang, Yi Xu, Wenyun Lu, Jonathan M. Ghergurovich, Lili Guo, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.

Original language	English (US)
Pages (from-to)	94-109.e8
Journal	Cell Metabolism
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2020.10.002
State	Published - Jan 5 2021

All Science Journal Classification (ASJC) codes

Molecular Biology
Physiology
Cell Biology

Keywords

G6PD
NAD kinase
NADPH
antioxidants
cancer metabolism
nucleosides
nucleotide synthesis
oncogenic transformation
pentose phosphate pathway
redox regulation

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10.1016/j.cmet.2020.10.002

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title = "Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation",

abstract = "The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.",

keywords = "G6PD, NAD kinase, NADPH, antioxidants, cancer metabolism, nucleosides, nucleotide synthesis, oncogenic transformation, pentose phosphate pathway, redox regulation",

author = "Yang Zhang and Yi Xu and Wenyun Lu and Ghergurovich, {Jonathan M.} and Lili Guo and Blair, {Ian A.} and Rabinowitz, {Joshua D.} and Xiaolu Yang",

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AU - Zhang, Yang

AU - Xu, Yi

AU - Lu, Wenyun

AU - Ghergurovich, Jonathan M.

AU - Guo, Lili

AU - Blair, Ian A.

AU - Rabinowitz, Joshua D.

AU - Yang, Xiaolu

PY - 2021/1/5

Y1 - 2021/1/5

N2 - The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.

AB - The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.

KW - G6PD

KW - NAD kinase

KW - NADPH

KW - antioxidants

KW - cancer metabolism

KW - nucleosides

KW - nucleotide synthesis

KW - oncogenic transformation

KW - pentose phosphate pathway

KW - redox regulation

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ER -

Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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