Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

Yang Zhang, Yi Xu, Wenyun Lu, Jonathan M. Ghergurovich, Lili Guo, Ian A. Blair, Joshua D. Rabinowitz, Xiaolu Yang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The basic elements required for oncogenic transformation remain undefined. By analyzing glucose-6-phosphate dehydrogenase (G6PD)-mediated oncogenic transformation, Zhang et al. show that upregulation of antioxidant defense and nucleotide production suffices to transform murine and human cells. Therefore, oncogenic transformation may involve overcoming a limited redox balance capacity and nucleotide precursor availability.

Original languageEnglish (US)
Pages (from-to)94-109.e8
JournalCell Metabolism
Volume33
Issue number1
DOIs
StatePublished - Jan 5 2021

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Keywords

  • G6PD
  • NAD kinase
  • NADPH
  • antioxidants
  • cancer metabolism
  • nucleosides
  • nucleotide synthesis
  • oncogenic transformation
  • pentose phosphate pathway
  • redox regulation

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