TY - JOUR
T1 - Updating of context in working memory
T2 - An event-related potential study
AU - Lenartowicz, Agatha
AU - Escobedo-Quiroz, Rafael
AU - Cohen, Jonathan D.
N1 - Funding Information:
Funding for this research was provided by the National Institutes of Health (NIMH) Grant 5 R01 MH052854, awarded to J.D.C. This work was completed with invaluable assistance in data analysis from Demetrios Voreades and Richard Greenblatt (Source Signal Imaging, Inc.), as well as useful design suggestions from Samuel M. McClure, John Kounios, and Steven Luck.
PY - 2010/6
Y1 - 2010/6
N2 - Flexible control of behavior depends on the representation, maintenance, and updating of context information in working memory, which is thought to rely on the prefrontal cortex (PFC). However, in contrast to maintenance, the dynamics of context activation and updating have not been well studied. To identify neural signals associated with context updating, we compared event-related potentials associated with cues that did or did not provide task-relevant context information. The earliest effect of context was detected 200 msec following cue onset and had a scalp topography consistent with a generator in the PFC. Subsequent effects of context were detected at 400-700 msec following cue onset (P3b), with a broad scalp distribution spanning posterior areas, and during the final 300 msec preceding the target, with a probable generator in the medial frontal cortex. We propose that the effect of context on P2 is consistent with the onset of context updating in the PFC. Subsequent components may be indicative of activation of task-relevant posterior regions and context maintenance.
AB - Flexible control of behavior depends on the representation, maintenance, and updating of context information in working memory, which is thought to rely on the prefrontal cortex (PFC). However, in contrast to maintenance, the dynamics of context activation and updating have not been well studied. To identify neural signals associated with context updating, we compared event-related potentials associated with cues that did or did not provide task-relevant context information. The earliest effect of context was detected 200 msec following cue onset and had a scalp topography consistent with a generator in the PFC. Subsequent effects of context were detected at 400-700 msec following cue onset (P3b), with a broad scalp distribution spanning posterior areas, and during the final 300 msec preceding the target, with a probable generator in the medial frontal cortex. We propose that the effect of context on P2 is consistent with the onset of context updating in the PFC. Subsequent components may be indicative of activation of task-relevant posterior regions and context maintenance.
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U2 - 10.3758/CABN.10.2.298
DO - 10.3758/CABN.10.2.298
M3 - Article
C2 - 20498352
AN - SCOPUS:77955843500
SN - 1530-7026
VL - 10
SP - 298
EP - 315
JO - Cognitive, Affective and Behavioral Neuroscience
JF - Cognitive, Affective and Behavioral Neuroscience
IS - 2
ER -