Upconverting nanophosphors for bioimaging

Shuang Fang Lim; Robert Riehn; Chih Kuan Tung; William S. Ryu; Rui Zhuo; Joanna Dalland; Robert H. Austin

doi:10.1088/0957-4484/20/40/405701

Upconverting nanophosphors for bioimaging

Shuang Fang Lim, Robert Riehn, Chih Kuan Tung, William S. Ryu, Rui Zhuo, Joanna Dalland, Robert H. Austin

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Upconverting nanoparticles(UCNPs) when excited in the near-infrared(NIR) region display anti-Stokes emission whereby the emitted photon is higher in energy than the excitation energy. The material system achieves that by converting two or more infrared photons into visible photons. The use of the infrared confers benefits to bioimaging because of its deeper penetrating power in biological tissues and the lack of autofluorescence. We demonstrate here sub-10nm, upconverting rare earth oxide UCNPs synthesized by a combustion method that can be stably suspended in water when amine modified. The amine modified UCNPs show specific surface immobilization onto patterned gold surfaces. Finally, the low toxicity of the UCNPs is verified by testing on the multi-cellular C.elegans nematode.

Original language	English (US)
Article number	405701
Journal	Nanotechnology
Volume	20
Issue number	40
DOIs	https://doi.org/10.1088/0957-4484/20/40/405701
State	Published - 2009

All Science Journal Classification (ASJC) codes

General Chemistry
Mechanics of Materials
Mechanical Engineering
Bioengineering
Electrical and Electronic Engineering
General Materials Science

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10.1088/0957-4484/20/40/405701

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title = "Upconverting nanophosphors for bioimaging",

abstract = "Upconverting nanoparticles(UCNPs) when excited in the near-infrared(NIR) region display anti-Stokes emission whereby the emitted photon is higher in energy than the excitation energy. The material system achieves that by converting two or more infrared photons into visible photons. The use of the infrared confers benefits to bioimaging because of its deeper penetrating power in biological tissues and the lack of autofluorescence. We demonstrate here sub-10nm, upconverting rare earth oxide UCNPs synthesized by a combustion method that can be stably suspended in water when amine modified. The amine modified UCNPs show specific surface immobilization onto patterned gold surfaces. Finally, the low toxicity of the UCNPs is verified by testing on the multi-cellular C.elegans nematode.",

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AU - Lim, Shuang Fang

AU - Riehn, Robert

AU - Tung, Chih Kuan

AU - Ryu, William S.

AU - Zhuo, Rui

AU - Dalland, Joanna

AU - Austin, Robert H.

PY - 2009

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AB - Upconverting nanoparticles(UCNPs) when excited in the near-infrared(NIR) region display anti-Stokes emission whereby the emitted photon is higher in energy than the excitation energy. The material system achieves that by converting two or more infrared photons into visible photons. The use of the infrared confers benefits to bioimaging because of its deeper penetrating power in biological tissues and the lack of autofluorescence. We demonstrate here sub-10nm, upconverting rare earth oxide UCNPs synthesized by a combustion method that can be stably suspended in water when amine modified. The amine modified UCNPs show specific surface immobilization onto patterned gold surfaces. Finally, the low toxicity of the UCNPs is verified by testing on the multi-cellular C.elegans nematode.

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Upconverting nanophosphors for bioimaging

Abstract

All Science Journal Classification (ASJC) codes

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