Unravelling the complexity of metastasis-molecular understanding and targeted therapies

Nilay Sethi, Yibin Kang

Research output: Contribution to journalReview article

250 Scopus citations

Abstract

Despite recognizing the devastating consequences of metastasis, we are not yet able to effectively treat cancer that has spread to vital organs. The inherent complexity of genomic alterations in late-stage cancers, coupled with numerous heterotypic interactions that occur between tumour and stromal cells, represent fundamental challenges in our quest to understand and control metastatic disease. The incorporation of genomic and other systems level approaches, as well as technological breakthroughs in imaging and animal modelling, have galvanized the effort to overcome gaps in our understanding of metastasis. Future research carries with it the potential to translate the wealth of new knowledge and conceptual advances into effective targeted therapies.

Original languageEnglish (US)
Pages (from-to)735-748
Number of pages14
JournalNature Reviews Cancer
Volume11
Issue number10
DOIs
StatePublished - Oct 1 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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