Abstract
During the last decade, major advances in the understanding of the mechanism of high altitude pulmonary edema (HAPE) have supplemented the landmark work done in the previous 30 years. A brief review of the earlier studies will be described, which will then be followed by a more complete treatise on the subsequent research, which has elucidated the role of accentuated pulmonary hypertension in the development of HAPE. Vasoactive mediators, such as nitric oxide (NO) and endothelin-1, have played a major role in this understanding and have led to preventive and therapeutic interventions. Additionally, the role of the alveolar epithelium and the Na-K ATPase pump in alveolar fluid clearance has also more recently been understood. Direction for future work will be given as well.
Original language | English (US) |
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Pages (from-to) | 125-135 |
Number of pages | 11 |
Journal | High Altitude Medicine and Biology |
Volume | 5 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 2004 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Physiology
- Public Health, Environmental and Occupational Health
Keywords
- Acclimatization
- Alveolar fluid clearance
- Endothelin-1
- Nitric oxide
- Pulmonary hypertension