TY - JOUR
T1 - Unit operations of tissue development
T2 - Epithelial folding
AU - Zartman, Jeremiah J.
AU - Shvartsman, Stanislav Y.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/7/15
Y1 - 2010/7/15
N2 - The development of multicellular organisms relies on a small set of construction techniques - assembly, sculpting, and folding - that are spatially and temporally regulated in a combinatorial manner to produce the diversity of tissues within the body. These basic processes are well conserved across tissue types and species at the level of both genes and mechanisms. Here we review the signaling, patterning, and biomechanical transformations that occur in two well-studied model systems of epithelial folding to illustrate both the complexity and modularity of tissue development. In particular, we discuss the possibility of a spatial code specifying morphogenesis. To decipher this code, engineers and scientists need to establish quantitative experimental systems and to develop models that address mechanisms at multiple levels of organization, from gene sequence to tissue biomechanics. In turn, quantitative models of embryogenesis can inspire novel methods for creating synthetic organs and treating degenerative tissue diseases.
AB - The development of multicellular organisms relies on a small set of construction techniques - assembly, sculpting, and folding - that are spatially and temporally regulated in a combinatorial manner to produce the diversity of tissues within the body. These basic processes are well conserved across tissue types and species at the level of both genes and mechanisms. Here we review the signaling, patterning, and biomechanical transformations that occur in two well-studied model systems of epithelial folding to illustrate both the complexity and modularity of tissue development. In particular, we discuss the possibility of a spatial code specifying morphogenesis. To decipher this code, engineers and scientists need to establish quantitative experimental systems and to develop models that address mechanisms at multiple levels of organization, from gene sequence to tissue biomechanics. In turn, quantitative models of embryogenesis can inspire novel methods for creating synthetic organs and treating degenerative tissue diseases.
KW - biomechanics
KW - embryogenesis
KW - organogenesis
KW - pattern formation
KW - quantitative
KW - systems biology
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U2 - 10.1146/annurev-chembioeng-073009-100919
DO - 10.1146/annurev-chembioeng-073009-100919
M3 - Article
C2 - 22432580
AN - SCOPUS:79952159595
VL - 1
SP - 231
EP - 246
JO - Annual Review of Chemical and Biomolecular Engineering
JF - Annual Review of Chemical and Biomolecular Engineering
SN - 1947-5438
ER -