Ullmann Diaryl Ether Synthesis: Rate Acceleration by 2,2,6,6-Tetramethylheptane-3,5-dione

Elizabeth Buck, Zhiguo Jake Song, David Tschaen, Peter G. Dormer, R. P. Volante, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

259 Scopus citations

Abstract

(matrix presented) In the copper salt catalyzed ether formation from aryl bromides or iodides and phenols, 2,2,6,6,-tetramethylheptane-3,5-dione (TMHD) was found to greatly accelerate the ordinarily difficult reaction, making it occur under more moderate temperatures and reaction times. A series catalysts. The reaction was shown to tolerate electron-rich aryl bromides and electron-neutral phenols.

Original languageEnglish (US)
Pages (from-to)1623-1626
Number of pages4
JournalOrganic Letters
Volume4
Issue number9
DOIs
StatePublished - May 2 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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