Two-photon imaging of neural activity in awake mobile mice

Daniel Dombeck; David Tank

doi:10.1101/pdb.top081810

Two-photon imaging of neural activity in awake mobile mice

Daniel Dombeck, David Tank

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A method for functional, cellular-resolution imaging of neural populations in awake and mobile mice is presented here. The method is based on the use of a spherical treadmill, head restraint, and motion correction software that facilitate neural imaging in the awake brain with a fixed upright two-photon microscope. These approaches have proven to be applicable to a wide range of brain regions and should help further our understanding of how neuronal population activity within the brain’s microcircuitry is connected to animal behavior.

Original language	English (US)
Pages (from-to)	726-736
Number of pages	11
Journal	Cold Spring Harbor Protocols
Volume	2014
Issue number	7
DOIs	https://doi.org/10.1101/pdb.top081810
State	Published - Jul 1 2014

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1101/pdb.top081810

Cite this

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Two-photon imaging of neural activity in awake mobile mice

Abstract

All Science Journal Classification (ASJC) codes

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