Tungsten complex induced dehydration of 2,3-dihydroxy-carboxylic acids to α-keto acids

Hye Kyung Bae Yu, Jeffrey Schwartz

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In the absence of added base, WOCl4 induces rapid dehydration of the title compounds to give α-keto acids. A mechanism is suggested based on a neighboring group effect.

Original languageEnglish (US)
Pages (from-to)6791-6794
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number45
DOIs
StatePublished - Nov 3 1992

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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