Tungsten complex induced dehydration of 2,3-dihydroxy-carboxylic acids to α-keto acids

Hye Kyung Bae Yu; Jeffrey Schwartz

doi:10.1016/S0040-4039(00)61777-X

Tungsten complex induced dehydration of 2,3-dihydroxy-carboxylic acids to α-keto acids

Hye Kyung Bae Yu, Jeffrey Schwartz

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In the absence of added base, WOCl₄ induces rapid dehydration of the title compounds to give α-keto acids. A mechanism is suggested based on a neighboring group effect.

Original language	English (US)
Pages (from-to)	6791-6794
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	45
DOIs	https://doi.org/10.1016/S0040-4039(00)61777-X
State	Published - Nov 3 1992

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)61777-X

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@article{9f8d428f3fa1458f980273f714ca85b5,

title = "Tungsten complex induced dehydration of 2,3-dihydroxy-carboxylic acids to α-keto acids",

abstract = "In the absence of added base, WOCl4 induces rapid dehydration of the title compounds to give α-keto acids. A mechanism is suggested based on a neighboring group effect.",

author = "{Bae Yu}, {Hye Kyung} and Jeffrey Schwartz",

year = "1992",

month = nov,

day = "3",

doi = "10.1016/S0040-4039(00)61777-X",

language = "English (US)",

volume = "33",

pages = "6791--6794",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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T1 - Tungsten complex induced dehydration of 2,3-dihydroxy-carboxylic acids to α-keto acids

AU - Bae Yu, Hye Kyung

AU - Schwartz, Jeffrey

PY - 1992/11/3

Y1 - 1992/11/3

N2 - In the absence of added base, WOCl4 induces rapid dehydration of the title compounds to give α-keto acids. A mechanism is suggested based on a neighboring group effect.

AB - In the absence of added base, WOCl4 induces rapid dehydration of the title compounds to give α-keto acids. A mechanism is suggested based on a neighboring group effect.

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U2 - 10.1016/S0040-4039(00)61777-X

DO - 10.1016/S0040-4039(00)61777-X

M3 - Article

AN - SCOPUS:0026485478

SN - 0040-4039

VL - 33

SP - 6791

EP - 6794

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 45

ER -

Tungsten complex induced dehydration of 2,3-dihydroxy-carboxylic acids to α-keto acids

Abstract

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