TY - JOUR
T1 - Tumor Cell Dissemination
T2 - Emerging Biological Insights from Animal Models and Cancer Patients
AU - Kang, Yibin
AU - Pantel, Klaus
N1 - Funding Information:
We thank Dr. Natalia Bednarz-Knoll for her technical assistance and members of our laboratories for helpful discussions. We also apologize to the many investigators whose important studies could not be cited directly here, owing to space limitations. The work was supported by the Advanced Investigator Grant “DISSECT” of the European Research Council (to K.P.) and grants from the Brewster Foundation, the Champalimaud Foundation, Komen for the Cure, and the National Institutes of Health (to Y.K.). Y.K. received a research grant from Amgen. K.P. received research grants and speaker’s honoria from Veridex.
PY - 2013/5/13
Y1 - 2013/5/13
N2 - Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.
AB - Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.
UR - http://www.scopus.com/inward/record.url?scp=84877816994&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877816994&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2013.04.017
DO - 10.1016/j.ccr.2013.04.017
M3 - Review article
C2 - 23680145
AN - SCOPUS:84877816994
SN - 1535-6108
VL - 23
SP - 573
EP - 581
JO - Cancer Cell
JF - Cancer Cell
IS - 5
ER -