Tumor Cell Dissemination: Emerging Biological Insights from Animal Models and Cancer Patients

Yibin Kang, Klaus Pantel

Research output: Contribution to journalReview article

237 Scopus citations

Abstract

Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.

Original languageEnglish (US)
Pages (from-to)573-581
Number of pages9
JournalCancer Cell
Volume23
Issue number5
DOIs
StatePublished - May 13 2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

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