Tube continued: Morphogenesis of the Drosophila tracheal system

Jodi Schottenfeld, Yanjun Song, Amin S. Ghabrial

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


The Drosophila respiratory organ (tracheal system) consists of epithelial tubes, the morphogenesis of which is controlled by distinct sets of signaling pathways and transcription factors. The downstream events controlling tube formation and shape are only now beginning to be identified. Here we review recent insight into the communication between neighboring tracheal cells, their interactions with the surrounding matrix, and the impact of these processes on tube morphogenesis. We focus on cell-cell interactions that drive rearrangement of cells within the epithelium and that are essential for maintenance of epithelial integrity, and also on cell-matrix interactions that play key roles in determining and maintaining the size and shape of tube lumens.

Original languageEnglish (US)
Pages (from-to)633-639
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number5
StatePublished - Oct 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology


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