Transport of lipopolysaccharide across the cell envelope: The long road of discovery

Natividad Ruiz, Daniel Kahne, Thomas J. Silhavy

Research output: Contribution to journalReview article

165 Scopus citations

Abstract

Intracellular lipid transport is poorly understood. Genetic studies to identify lipid-transport factors are complicated by the essentiality of many lipids, whereas biochemical and cell biology approaches aiming to determine localization and mechanisms of lipid transport are often challenged by the lack of adequate technology. Here, we review the epic history of how different approaches, technological advances and ingenuity contributed to the recent discovery of a multi-protein pathway that transports lipopolysaccharide across the envelope of Gram-negative bacteria.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalNature Reviews Microbiology
Volume7
Issue number9
DOIs
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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