TY - JOUR
T1 - Transplantable mouse tumor models of breast cancer metastasis
AU - Chakrabarti, Rumela
AU - Kang, Yibin
PY - 2015
Y1 - 2015
N2 - Metastatic spread of cancer cells is the main cause of death of breast cancer patients. A better understanding of the molecular mechanism of cancer metastasis is essential for the development of novel and effective therapies. The biological complexity of the metastasis process requires the combination of multiple experimental systems to model distinct steps of cancer metastasis. Several animal models have been generated to mimic the process of breast cancer metastasis, with unique advantages and drawbacks of each model. In this chapter, we describe transplantable xenograft and allograft methods to introduce human or mouse breast tumor cells into mice in order to generate spontaneous and experimental metastasis.
AB - Metastatic spread of cancer cells is the main cause of death of breast cancer patients. A better understanding of the molecular mechanism of cancer metastasis is essential for the development of novel and effective therapies. The biological complexity of the metastasis process requires the combination of multiple experimental systems to model distinct steps of cancer metastasis. Several animal models have been generated to mimic the process of breast cancer metastasis, with unique advantages and drawbacks of each model. In this chapter, we describe transplantable xenograft and allograft methods to introduce human or mouse breast tumor cells into mice in order to generate spontaneous and experimental metastasis.
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U2 - 10.1007/978-1-4939-2297-0_18
DO - 10.1007/978-1-4939-2297-0_18
M3 - Article
C2 - 25636479
AN - SCOPUS:84954623332
SN - 1064-3745
VL - 1267
SP - 367
EP - 380
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -