Transmission consequences of coinfection: cytokines writ large?

Andrea L. Graham, Isabella M. Cattadori, James O. Lloyd-Smith, Matthew J. Ferrari, Ottar N. Bjørnstad

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

Coinfection of a host by multiple parasite species is commonly observed and recent epidemiological work indicates that coinfection can enhance parasite transmission. This article proposes an immunoepidemiological framework to understand how within-host interactions during coinfection might affect between-host transmission. Cytokines, immune signalling molecules with a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way to simplify immunological complexity for this endeavour - focusing on cytokines offers analytical tractability without sacrificing realism. Testable predictions about the epidemiological consequences of coinfection are generated by this conceptual framework.

Original languageEnglish (US)
Pages (from-to)284-291
Number of pages8
JournalTrends in Parasitology
Volume23
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

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