Transition-path theory and path-finding algorithms for the study of rare events

Weinan E, Eric Vanden-Eijnden

Research output: Contribution to journalArticlepeer-review

458 Scopus citations


Transition-path theory is a theoretical framework for describing rare events in complex systems. It can also be used as a starting point for developing efficient numerical algorithms for analyzing such rare events. Here we review the basic components of transition-path theory and path-finding algorithms. We also discuss connections with the classical transition-state theory.

Original languageEnglish (US)
Pages (from-to)391-420
Number of pages30
JournalAnnual Review of Physical Chemistry
StatePublished - May 5 2010

All Science Journal Classification (ASJC) codes

  • General Medicine


  • Activated process
  • Minimum free energy path
  • String method
  • Transition-state theory


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