Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum

Elizabeth Gould; Larry L. Butcher

doi:10.1016/0165-3806(87)90218-5

Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum

Elizabeth Gould
, Larry L. Butcher

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The expression of choline acetyltransferase (ChAT)-like immunoreactivity was studied immunohistochemically in the cerebelli of developing rats. Brains were examined from the day of birth (postnatal day 1: P1) until adulthood. From P4 through P21, several Purkinje cells in the uvula, nodule, and flocculus of the cerebellum demonstrated ChAT-like immunoreactivity. After P23, no ChAT-positive neurons were observed in any region of the cerebellum. This finding paralleled the transient expression of acetylcholinesterase in Purkinje cells of these same cerebellar areas during development.

Original language	English (US)
Pages (from-to)	303-306
Number of pages	4
Journal	Developmental Brain Research
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(87)90218-5
State	Published - Aug 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Developmental Neuroscience
Developmental Biology

Keywords

Acetylcholinesterase
Cerebellum
Choline acetyltransferase immunohistochemistry
Development
Purkinje cell

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10.1016/0165-3806(87)90218-5

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title = "Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum",

abstract = "The expression of choline acetyltransferase (ChAT)-like immunoreactivity was studied immunohistochemically in the cerebelli of developing rats. Brains were examined from the day of birth (postnatal day 1: P1) until adulthood. From P4 through P21, several Purkinje cells in the uvula, nodule, and flocculus of the cerebellum demonstrated ChAT-like immunoreactivity. After P23, no ChAT-positive neurons were observed in any region of the cerebellum. This finding paralleled the transient expression of acetylcholinesterase in Purkinje cells of these same cerebellar areas during development.",

keywords = "Acetylcholinesterase, Cerebellum, Choline acetyltransferase immunohistochemistry, Development, Purkinje cell",

author = "Elizabeth Gould and Butcher, \{Larry L.\}",

note = "Funding Information: This research was supported by USPHS Grant NS-10928 to L.L.B. Dr. Felix Eckenstein is thanked for generous supplies of the monoclonal antibody against CHAT.",

year = "1987",

month = aug,

doi = "10.1016/0165-3806(87)90218-5",

language = "English (US)",

volume = "34",

pages = "303--306",

journal = "Developmental Brain Research",

issn = "0165-3806",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum

AU - Gould, Elizabeth

AU - Butcher, Larry L.

N1 - Funding Information: This research was supported by USPHS Grant NS-10928 to L.L.B. Dr. Felix Eckenstein is thanked for generous supplies of the monoclonal antibody against CHAT.

PY - 1987/8

Y1 - 1987/8

N2 - The expression of choline acetyltransferase (ChAT)-like immunoreactivity was studied immunohistochemically in the cerebelli of developing rats. Brains were examined from the day of birth (postnatal day 1: P1) until adulthood. From P4 through P21, several Purkinje cells in the uvula, nodule, and flocculus of the cerebellum demonstrated ChAT-like immunoreactivity. After P23, no ChAT-positive neurons were observed in any region of the cerebellum. This finding paralleled the transient expression of acetylcholinesterase in Purkinje cells of these same cerebellar areas during development.

AB - The expression of choline acetyltransferase (ChAT)-like immunoreactivity was studied immunohistochemically in the cerebelli of developing rats. Brains were examined from the day of birth (postnatal day 1: P1) until adulthood. From P4 through P21, several Purkinje cells in the uvula, nodule, and flocculus of the cerebellum demonstrated ChAT-like immunoreactivity. After P23, no ChAT-positive neurons were observed in any region of the cerebellum. This finding paralleled the transient expression of acetylcholinesterase in Purkinje cells of these same cerebellar areas during development.

KW - Acetylcholinesterase

KW - Cerebellum

KW - Choline acetyltransferase immunohistochemistry

KW - Development

KW - Purkinje cell

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U2 - 10.1016/0165-3806(87)90218-5

DO - 10.1016/0165-3806(87)90218-5

M3 - Article

C2 - 3304542

AN - SCOPUS:0023225307

SN - 0165-3806

VL - 34

SP - 303

EP - 306

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 2

ER -

Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum

Abstract

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