Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum

Elizabeth Gould, Larry L. Butcher

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The expression of choline acetyltransferase (ChAT)-like immunoreactivity was studied immunohistochemically in the cerebelli of developing rats. Brains were examined from the day of birth (postnatal day 1: P1) until adulthood. From P4 through P21, several Purkinje cells in the uvula, nodule, and flocculus of the cerebellum demonstrated ChAT-like immunoreactivity. After P23, no ChAT-positive neurons were observed in any region of the cerebellum. This finding paralleled the transient expression of acetylcholinesterase in Purkinje cells of these same cerebellar areas during development.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalDevelopmental Brain Research
Volume34
Issue number2
DOIs
StatePublished - Aug 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Keywords

  • Acetylcholinesterase
  • Cerebellum
  • Choline acetyltransferase immunohistochemistry
  • Development
  • Purkinje cell

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