Transcripts encoded by a homoeo box gene are restricted to dorsal tissues of Drosophila embryos

Helen J. Doyle, Katherine Harding, Timothy Hoey, Michael Levine

Research output: Contribution to journalArticle

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Abstract

In Drosophila elaboration of positional identity along the anterior-posterior and dorsal-ventral embryonic body axes involves early zygotic gene functions that are expressed in response to maternal cues present in the unfertilized egg1. Zygotic loci that are required for the specification of positional identity along the anterior-posterior body axis have been described in detail2-9. Less is known about the zygotic loci responsible for differentiation of the dorsal-ventral pattern; however, several genes that might be involved have been identified3-5,10. Zerkn̈llt (zen) is an example of a zygotic gene required for correct differentiation of dorsally derived embryonic tissues10. On the basis of homoeo box cross homology, we have now isolated a gene, called S60, that derives from the zen region of the Antennapedia complex (ANT-C)7,10. Transcripts encoded by S60 transiently accumulate in the dorsal-most tissues of developing embryos. This pattern of expression suggests that S60 corresponds to zen. Since S60 contains a homoeo box, it is possible that differentiation of the anterior-posterior and dorsal-ventral embryonic patterns involves similar molecular mechanisms.

Original languageEnglish (US)
Pages (from-to)76-79
Number of pages4
JournalNature
Volume323
Issue number6083
DOIs
StatePublished - Dec 1 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

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