Transcriptional coregulators in development

Mattias Mannervik, Yutaka Nibu, Hailan Zhang, Michael Steven Levine

Research output: Contribution to journalReview article

185 Scopus citations

Abstract

Small differences in the levels of an extracellular signaling moLecuLe can specify cell fate during development. Threshold responses are often determined at the level of transcription. Cell-specific and spatially localized patterns of gene expression depend on combinations of sequence- specific activators and repressors that bind to extensive cis-regulatory regions. Different mechanisms for integrating this complex regulatory information are discussed, particularly the rote of coregulatory proteins, which are recruited to the DNA template by sequence-specific transcription factors. Recent studies surest that a growing set of coactivators and corepressors mediate communication between diverse upstream regulatory proteins and the core RNA polymerase II transcription complex.

Original languageEnglish (US)
Pages (from-to)606-609
Number of pages4
JournalScience
Volume284
Issue number5414
DOIs
StatePublished - Apr 23 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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