TY - JOUR
T1 - Transcriptional control of cancer metastasis
AU - Ell, Brian
AU - Kang, Yibin
N1 - Funding Information:
We apologize to researchers whose studies we were unable to cite due to the space limitation of this review. Research in our laboratory is supported by grants from the National Institutes of Health (R01CA134519 and R01CA141062), the Department of Defense (BC123187), Komen for the Cure, the Brewster Foundation, and the Champalimaud Foundation.
PY - 2013/12
Y1 - 2013/12
N2 - Transcriptional regulation is an essential component of tumor progression and metastasis. During cancer progression, dysregulation of oncogenic or tumor-suppressive transcription factors (TFs), as well as master cell fate regulators and tumor microenvironment-induced factors, collectively influence multiple steps of the metastasis cascade, including local invasion, dissemination, and eventual colonization of the tumor to distant organs. Furthermore, epigenetic alterations in tumor cells, including DNA methylation, as well as activation or suppression of histone deacetylases (HDACs), histone acetyltransferases (HATs), and other chromatin-modifying enzymes, can further distort the transcriptional network to influence metastasis. We focus here on recent research advances in transcriptional control of metastasis and highlight the therapeutic potential of targeting such transcriptional regulatory networks.
AB - Transcriptional regulation is an essential component of tumor progression and metastasis. During cancer progression, dysregulation of oncogenic or tumor-suppressive transcription factors (TFs), as well as master cell fate regulators and tumor microenvironment-induced factors, collectively influence multiple steps of the metastasis cascade, including local invasion, dissemination, and eventual colonization of the tumor to distant organs. Furthermore, epigenetic alterations in tumor cells, including DNA methylation, as well as activation or suppression of histone deacetylases (HDACs), histone acetyltransferases (HATs), and other chromatin-modifying enzymes, can further distort the transcriptional network to influence metastasis. We focus here on recent research advances in transcriptional control of metastasis and highlight the therapeutic potential of targeting such transcriptional regulatory networks.
KW - Epigenetics
KW - Epithelial-mesenchymal transition
KW - Metastasis
KW - Transcription factors
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=84888205667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888205667&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2013.06.001
DO - 10.1016/j.tcb.2013.06.001
M3 - Review article
C2 - 23838335
AN - SCOPUS:84888205667
SN - 0962-8924
VL - 23
SP - 603
EP - 611
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 12
ER -