Transcription regulation and animal diversity

Michael Levine; Robert Tjian

doi:10.1038/nature01763

Transcription regulation and animal diversity

Michael Levine, Robert Tjian

Research output: Contribution to journal › Review article › peer-review

987 Scopus citations

Abstract

Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.

Original language	English (US)
Pages (from-to)	147-151
Number of pages	5
Journal	Nature
Volume	424
Issue number	6945
DOIs	https://doi.org/10.1038/nature01763
State	Published - Jul 10 2003
Externally published	Yes

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title = "Transcription regulation and animal diversity",

abstract = "Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.",

author = "Michael Levine and Robert Tjian",

note = "Funding Information: Acknowledgements We thank Y. Nibu, A. Ladurner and J. Ziegalbauer for preparing the figures. We also thank D. Rio and L. Mirels for critically reviewing the manuscript. M.L is supported by the NIH and R.T. is funded in part by a grant from the NIH.",

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AU - Tjian, Robert

N1 - Funding Information: Acknowledgements We thank Y. Nibu, A. Ladurner and J. Ziegalbauer for preparing the figures. We also thank D. Rio and L. Mirels for critically reviewing the manuscript. M.L is supported by the NIH and R.T. is funded in part by a grant from the NIH.

PY - 2003/7/10

Y1 - 2003/7/10

N2 - Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.

AB - Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.

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JO - Nature

JF - Nature

IS - 6945

ER -

Transcription regulation and animal diversity

Abstract

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