Transcription regulation and animal diversity

Michael Levine, Robert Tjian

Research output: Contribution to journalReview articlepeer-review

858 Scopus citations

Abstract

Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalNature
Volume424
Issue number6945
DOIs
StatePublished - Jul 10 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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