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Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines.

  • Ioannis N. Houpis
  • , Audrey Molina
  • , Robert A. Reamer
  • , Joseph E. Lynch
  • , R. P. Volante
  • , Paul J. Reider

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the readily available optically pure monoacid 4.

Original languageEnglish (US)
Pages (from-to)2593-2596
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number16
DOIs
StatePublished - Apr 16 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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