Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines.

Ioannis N. Houpis; Audrey Molina; Robert A. Reamer; Joseph E. Lynch; R. P. Volante; Paul J. Reider

doi:10.1016/S0040-4039(00)77633-7

Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines.

Ioannis N. Houpis, Audrey Molina, Robert A. Reamer, Joseph E. Lynch, R. P. Volante, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the readily available optically pure monoacid 4.

Original language	English (US)
Pages (from-to)	2593-2596
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	16
DOIs	https://doi.org/10.1016/S0040-4039(00)77633-7
State	Published - Apr 16 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)77633-7

Cite this

@article{2ddfe90cd89e4573bf26ed72d06afec3,

title = "Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines.",

abstract = "The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the readily available optically pure monoacid 4.",

author = "Houpis, {Ioannis N.} and Audrey Molina and Reamer, {Robert A.} and Lynch, {Joseph E.} and Volante, {R. P.} and Reider, {Paul J.}",

year = "1993",

month = apr,

day = "16",

doi = "10.1016/S0040-4039(00)77633-7",

language = "English (US)",

volume = "34",

pages = "2593--2596",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "16",

}

TY - JOUR

T1 - Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines.

AU - Houpis, Ioannis N.

AU - Molina, Audrey

AU - Reamer, Robert A.

AU - Lynch, Joseph E.

AU - Volante, R. P.

AU - Reider, Paul J.

PY - 1993/4/16

Y1 - 1993/4/16

N2 - The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the readily available optically pure monoacid 4.

AB - The synthesis of optically pure decahydroisoquinoline 1, a component of HIV-protease inhibitors, was accomplished in 30-33% overall yield from the readily available optically pure monoacid 4.

UR - http://www.scopus.com/inward/record.url?scp=0027474335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027474335&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)77633-7

DO - 10.1016/S0040-4039(00)77633-7

M3 - Article

AN - SCOPUS:0027474335

SN - 0040-4039

VL - 34

SP - 2593

EP - 2596

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 16

ER -

Towards the synthesis of HIV-protease inhibitors. Synthesis optically pure 3-carboxyl-decahydroisoquinolines.

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this