Toward the dynamic interactome: It's about time

Teresa M. Przytycka, Mona Singh, Donna K. Slonim

Research output: Contribution to journalArticlepeer-review

198 Scopus citations


Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior. Published by Oxford University Press. For Permissions, please email:

Original languageEnglish (US)
Article numberbbp057
Pages (from-to)15-29
Number of pages15
JournalBriefings in Bioinformatics
Issue number1
StatePublished - Jan 8 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Molecular Biology


  • Interaction networks
  • Network analysis
  • Network dynamics
  • Systems biology


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