Toward the dynamic interactome: It's about time

Teresa M. Przytycka, Mona Singh, Donna K. Slonim

Research output: Contribution to journalArticle

168 Scopus citations

Abstract

Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior. Published by Oxford University Press. For Permissions, please email: journals.permissions@oxfordjournals.org.

Original languageEnglish (US)
Article numberbbp057
Pages (from-to)15-29
Number of pages15
JournalBriefings in Bioinformatics
Volume11
Issue number1
DOIs
StatePublished - Jan 8 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Molecular Biology

Keywords

  • Interaction networks
  • Network analysis
  • Network dynamics
  • Systems biology

Fingerprint Dive into the research topics of 'Toward the dynamic interactome: It's about time'. Together they form a unique fingerprint.

  • Cite this