Toward a mild dehydroformylation using base-metal catalysis

Dylan J. Abrams, Julian G. West, Erik J. Sorensen

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Dehydroformylation, or the reaction of aldehydes to produce alkenes, hydrogen gas, and carbon monoxide, is a powerful transformation that is underdeveloped despite the high industrial importance of the reverse reaction, hydroformylation. Interestingly, nature routinely performs a related transformation, oxidative dehydroformylation, in the biosynthesis of cholesterol and related sterols under mild conditions using base-metal catalysts. In contrast, chemists have recently developed a non-oxidative dehydroformylation method; however, it requires high temperatures and a precious-metal catalyst. Careful study of both approaches has informed our efforts to design a base-metal catalyzed, mild dehydroformylation method that incorporates benefits from each while avoiding several of their respective disadvantages. Importantly, we show that cooperative base metal catalysis presents a powerful, mechanistically unique approach to reactions which are difficult to achieve using conventional catalyst design.

Original languageEnglish (US)
Pages (from-to)1954-1959
Number of pages6
JournalChemical Science
Volume8
Issue number3
DOIs
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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