Total synthesis of thienamycin: a new approach from aspartic acid

Paul J. Reider, Edward J.J. Grabowski

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

A practical stereospecific synthesis of thienamycin 1 has been achieved. Key steps include a lead tetracetate oxidative decarboxylation and subsequent insertion of a four carbon diazo containing unit into a 3-acetoxy-2-azetidinene.

Original languageEnglish (US)
Pages (from-to)2293-2296
Number of pages4
JournalTetrahedron Letters
Volume23
Issue number22
DOIs
StatePublished - 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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