Total synthesis of thienamycin: a new approach from aspartic acid

Paul J. Reider; Edward J.J. Grabowski

doi:10.1016/S0040-4039(00)87324-4

Total synthesis of thienamycin: a new approach from aspartic acid

Paul J. Reider, Edward J.J. Grabowski

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

A practical stereospecific synthesis of thienamycin 1 has been achieved. Key steps include a lead tetracetate oxidative decarboxylation and subsequent insertion of a four carbon diazo containing unit into a 3-acetoxy-2-azetidinene.

Original language	English (US)
Pages (from-to)	2293-2296
Number of pages	4
Journal	Tetrahedron Letters
Volume	23
Issue number	22
DOIs	https://doi.org/10.1016/S0040-4039(00)87324-4
State	Published - 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)87324-4

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title = "Total synthesis of thienamycin: a new approach from aspartic acid",

abstract = "A practical stereospecific synthesis of thienamycin 1 has been achieved. Key steps include a lead tetracetate oxidative decarboxylation and subsequent insertion of a four carbon diazo containing unit into a 3-acetoxy-2-azetidinene.",

author = "Reider, {Paul J.} and Grabowski, {Edward J.J.}",

year = "1982",

doi = "10.1016/S0040-4039(00)87324-4",

language = "English (US)",

volume = "23",

pages = "2293--2296",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "22",

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T1 - Total synthesis of thienamycin

T2 - a new approach from aspartic acid

AU - Reider, Paul J.

AU - Grabowski, Edward J.J.

PY - 1982

Y1 - 1982

N2 - A practical stereospecific synthesis of thienamycin 1 has been achieved. Key steps include a lead tetracetate oxidative decarboxylation and subsequent insertion of a four carbon diazo containing unit into a 3-acetoxy-2-azetidinene.

AB - A practical stereospecific synthesis of thienamycin 1 has been achieved. Key steps include a lead tetracetate oxidative decarboxylation and subsequent insertion of a four carbon diazo containing unit into a 3-acetoxy-2-azetidinene.

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U2 - 10.1016/S0040-4039(00)87324-4

DO - 10.1016/S0040-4039(00)87324-4

M3 - Article

AN - SCOPUS:0020399702

SN - 0040-4039

VL - 23

SP - 2293

EP - 2296

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 22

ER -

Total synthesis of thienamycin: a new approach from aspartic acid

Abstract

All Science Journal Classification (ASJC) codes

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