Torso RTK controls Capicua degradation by changing its subcellular localization

Oliver Grimm, Victoria Sanchez Zini, Yoosik Kim, Jordi Casanova, Stanislav Y. Shvartsman, Eric Wieschaus

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The transcriptional repressor Capicua (Cic) controls multiple aspects of Drosophila embryogenesis and has been implicated in vertebrate development and human diseases. Receptor tyrosine kinases (RTKs) can antagonize Cic-dependent gene repression, but the mechanisms responsible for this effect are not fully understood. Based on genetic and imaging studies in the early Drosophila embryo, we found that Torso RTK signaling can increase the rate of Cic degradation by changing its subcellular localization. We propose that Cic is degraded predominantly in the cytoplasm and show that Torso reduces the stability of Cic by controlling the rates of its nucleocytoplasmic transport. This model accounts for the experimentally observed spatiotemporal dynamics of Cic in the early embryo and might explain RTK-dependent control of Cic in other developmental contexts.

Original languageEnglish (US)
Pages (from-to)3962-3968
Number of pages7
JournalDevelopment (Cambridge)
Volume139
Issue number21
DOIs
StatePublished - Nov 1 2012

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • Drosophila
  • Repressor
  • Rtk
  • Signaling

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